Haploidentical Bone Marrow Transplant (BMT) in India
- Haploidentical bone marroww transplant (BMT) is a type of allogeneic transplant where the donor and recipient share half of their human leukocyte antigen (HLA) markers. This approach is particularly significant in pediatrics, as it can provide a viable option for children who may not have fully matched siblings or unrelated donors.
- A haploidentical transplant involves a donor who is a half-match for the recipient, commonly a parent or other close relative.
Types of Haploidentical BMT
- Haploidentical Bone Marrow Transplant:Stem cells are harvested directly from the donor’s bone marroww, typically from the iliac crest.
- Haploidentical Peripheral Blood Stem Cell Transplant (PBSC):Stem cells are collected from the donor’s peripheral blood after mobilization with growth factors (e.g., G-CSF).
Indications for Haploidentical Transplant
- Hematological malignancies (e.g., leukemia, lymphoma) .
- Non-malignant disorders (e.g., sickle cell disease, thalassemia) .
- Situations of relapsed or refractory diseases
Donor Selection
- Standards for choosing haploidentical contributors (regularly relatives) .
- Role of donor registries and matching algorithms
- Challenges in finding suitable haploidentical donors.
Pre-Transplant Evaluation
- Comprehensive patient assessment and eligibility criteria .
- Psychological and social evaluations for patients and families
- Pre-treatment protocols and informed consent process
The Transplant Procedure
- Conditioning regimen (chemotherapy and/or radiation) .
- Infusion of stem cells from haploidentical donor
- Monitoring during and after the procedure
Complications and Management
- Risks of graft-versus-host disease (GVHD) .
- Infection risks and management strategies .
- Long-term follow-up care and monitoring for late effects
Recent Advances and Research
- Innovations in haploidentical transplant techniques .
- Role of immunotherapy and new treatment modalities .
- Progressing research and clinical preliminaries in India.
Conclusion
- Haploidentical BMT is a valuable option for pediatric patients needing a stem cell transplant.
- With advances in techniques and supportive care, many children benefit from this approach, which can lead to improved survival rates and quality of life.
- Families should work closely with a specialized transplant team to navigate the complexities of the process effectively.
Departments
Blood Cancer
Sickle Cell Anaemia
Allogeneic Transplant
Haploidentical Transplant
Syngeneic Transplant
Related Hospitals
Indraprastha Apollo Hospitals (Jasola, Delhi)
Max Super Specialty Hospital Gurgaon
Artemis Hospital (Gurgaon)
Jaypee Hospital Noida Delhi NCR India
