Pediatric Allogeneic Bone Marrow Transplant (BMT) in India

  • Pediatric allogeneic bone marroww transplantation (BMT) involves the transplantation of stem cells from a matched donor to treat various hematologic conditions in children.
  • This procedure is particularly crucial for treating cancers, genetic disorders, and bone marroww failures.
  • Here’s an overview of pediatric allogeneic BMT, including indications, process, and considerations.

 Types of Allogeneic BMT

  • Matched sibling donor transplant .
  • Matched unrelated donor transplant .
  • Haploidentical transplant (half-matched donor) .
  • Umbilical cord blood transplant

Indications for Pediatric Allogeneic BMT

  • Hematological malignancies .
  • Acute lymphoblastic leukemia (ALL) .
  • Acute myeloid leukemia (AML) .
  • Lymphoma B. Non-malignant disorders .
  • Thalassemia .
  • Sickle cell disease .
  • Aplastic anemia .
  • Genetic and metabolic disorders

Donor Selection

  • Criteria for selecting suitable donors .
  • Outline of the technique and its likely advantages .
  • Challenges in finding matched donors.

Pre-Transplant Evaluation

  • Comprehensive assessment of the pediatric patient .
  • Psychological and social evaluations for families 
  • Pre-treatment protocols and informed consent

The Transplant Procedure

  • Conditioning regimen (chemotherapy and/or radiation) .
  • Mixture of undifferentiated organisms from the allogeneic contributor .
  • Monitoring and supportive care during and after the procedure

Complications and Management

  • Risks of graft-versus-host disease (GVHD) .
  • Infection risks and management strategies .
  • Long haul follow-up and checking for late impacts

Recent Advances and Research

  • Innovations in transplant techniques and protocols .
  • Role of immunotherapy and targeted therapies .
  • Ongoing clinical trials and research initiatives in India

Conclusion

  • Pediatric allogeneic bone marroww transplantation is a complex but potentially life-saving procedure for children with severe hematologic and genetic disorders.
  • With advancements in donor matching, conditioning regimens, and supportive care, the outcomes for pediatric patients continue to improve.
  • A multidisciplinary approach, including careful pre-transplant evaluation and ongoing follow-up, is essential for optimizing the success of the transplant and the overall well-being of the patient.
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Departments

Blood Cancer

Sickle Cell Anaemia

Allogeneic Transplant

Haploidentical Transplant

Syngeneic Transplant

Related Hospitals

Indraprastha Apollo Hospitals (Jasola, Delhi)

Max Super Specialty Hospital Gurgaon

Artemis Hospital (Gurgaon)

Jaypee Hospital Noida Delhi NCR India

Narayana Superspecialty Hospital Gurgaon

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