Pediatric Autologous Bone Marrow Transplant (BMT) in India

  • In an autologous bone marroww transplant, stem cells are harvested from the child’s own bone marroww or blood, processed, and then reinfused after intensive treatment, usually chemotherapy or radiation.
  • Pediatric autologous bone marroww transplant (ABMT) is a medical procedure used to treat various conditions in children, including certain cancers (like leukemia and lymphoma), blood disorders, and immune deficiencies

 Types of Pediatric Autologous BMT

  • Bone Marrow Harvesting:Stem cells are directly collected from the child’s bone marroww, typically from the hip bone (iliac crest) under anesthesia.

  • Peripheral Blood Stem Cell (PBSC) Collection:Stem cells are mobilized into the bloodstream using growth factors and then collected through apheresis, a process that separates stem cells from other blood components.

Indications for Pediatric Autologous BMT

  • Hematological malignancies 
  • Acute lymphoblastic leukemia (ALL) .
  • Hodgkin and non-Hodgkin lymphoma .
  • Neuroblastoma .
  • Non-malignant disorders .
  • Severe aplastic anemia .
  • Thalassemia (in specific cases) .
  • Other conditions (e.g., certain autoimmune diseases)

Donor Selection

  • No Donor Needed: In autologous transplants, the child is their own donor, so there’s no external donor selection process.
  • Stem Cell Harvesting: Stem cells are collected from the child’s own bone marroww or peripheral blood. The health and quality of the child’s stem cells are assessed before harvesting.

Pre-Transplant Evaluation

  • Comprehensive assessment of the pediatric patient .
  • Psychological evaluations for families .
  • Pre-treatment protocols and informed consent process

The Transplant Procedure

  • Conditioning regimen (chemotherapy and/or radiation) .
  • Infusion of the patient’s own stem cells .
  • Monitoring and supportive care during and after the procedure

Complications and Management

  • Risks of graft-versus-host disease (GVHD) .
  • Infection risks and management strategies .
  • Long haul follow-up and checking for late impacts

Recent Advances and Research

  • Risks associated with autologous BMT .
  • Management of side effects (e.g., infections, fatigue) .
  • Long-term follow-up care and monitoring for late effects

Conclusion

  • Pediatric autologous BMT is a viable option for treating various conditions in children in India.
  • With advancements in medical technology and increasing expertise, the success rates and overall outcomes for pediatric patients are improving.
  • Families should work closely with their healthcare providers to navigate the treatment process effectively.
Book appointment

Departments

Blood Cancer

Sickle Cell Anaemia

Allogeneic Transplant

Haploidentical Transplant

Syngeneic Transplant

Related Hospitals

Indraprastha Apollo Hospitals (Jasola, Delhi)

Max Super Specialty Hospital Gurgaon

Artemis Hospital (Gurgaon)

Jaypee Hospital Noida Delhi NCR India

Narayana Superspecialty Hospital Gurgaon

Book appointment